Remy LeBeau was adopted into the Thieves Guild of New Orleans as a young child. By the time he was a young adult he was considered one of the Guild’s best and brightest. The leader of the Thieves Guild, Candra, joined forces with Apocalypse and became one of his Horsemen. This only marked her for attacks during the Horsemen’s War of Succession and she was murdered by Holocaust.
Gambit fled and hid in the ruins of New Orleans. He found himself caught in the middle of a battle between Magneto’s X-Men and a small band of Apocalypse’s Infinite soldiers. Gambit could have slipped away quietly but he chose to help the X-Men and saved the life of Magneto, preventing Alex Summers from killing him with a plasma blast.